HLA-B27 antigen in spondyloarthritis in sub-Saharan Africa: the example of Senegal.

Volume 4, Issue 4, August 2020     |     PP. 69-76      |     PDF (144 K)    |     Pub. Date: September 22, 2020
DOI:    192 Downloads     5846 Views  

Author(s)

Kaba Condé, 1Rheumatology Department, Ignace Deen University Hospital Center, Conakry, Guinea
Hugues Ghislain Atakla, Neurology Department, Ignace Deen University Hospital Center, Conakry, Guinea
Mahaman Salissou Garba, Rheumatology Department, Maradi National Hospital, Niamey, Niger
Moustapha Niasse, Rheumatology Department, Aristide Le Dantec University Hospital Centre, Dakar, Senegal
Rama Diallo, Rheumatology Department, Aristide Le Dantec University Hospital Centre, Dakar, Senegal
Coumba Diouf, Rheumatology Department, Aristide Le Dantec University Hospital Centre, Dakar, Senegal
Saïdou Diallo, Rheumatology Department, Aristide Le Dantec University Hospital Centre, Dakar, Senegal

Abstract
Objective. The aim of this study is to evaluate the presence of the HLA-B27 antigen in SpA in Senegalese hospitals. Patients and method: This is a retrospective study carried out in the rheumatology department of the CHU Le Dantec in Dakar between January 2012 and January 2017. The diagnosis of spondyloarthritis was retained, in accordance with the criteria of Assessment of Spondyloarthrisis and New York modified. For each patient, the following data were collected: age, sex, time to diagnosis, type of SpA, HLA B27 phenotyping. Results: We collected 209 observations of spondyloarthritis with a mean age of 46 years (extremes 20 and 66 years), 137 (65.6%) were women. The mean time to diagnosis was 5 years. Axial involvement was lumbar for 180 cases (86%). HLA-B 27 phenotyping was performed in all patients, 108 patients were HLA-B 27 positive (51.7%). These patients were slightly younger with a mean age of 38 years (extremes 20 and 55 years). Among the 108 HLA-B27 positive patients, 53/109 (48.6%) were from the Peulh (Fula) ethnic group. An AS was found in 88/109 cases (80.7%) and all patients with uveitis were HLA-B27 positive. Conclusion: Spondyloarthritis is growing in Senegalese hospitals. They mainly affect women and the HLA-27 antigen is present in half of the cases.

Keywords
Spondyloarthritis, HLA-B27, Senegal

Cite this paper
Kaba Condé, Hugues Ghislain Atakla, Mahaman Salissou Garba, Moustapha Niasse, Rama Diallo, Coumba Diouf, Saïdou Diallo, HLA-B27 antigen in spondyloarthritis in sub-Saharan Africa: the example of Senegal. , SCIREA Journal of Medicine. Volume 4, Issue 4, August 2020 | PP. 69-76.

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